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Genetic Mutations Meckel syndrome is associated with an autosomal recessive mutation in at least one of 13 genes. Mutations in these eight genes account for approximately 75% of Meckel-Gruber cases. The other 25% are caused by mutations that have yet to be discovered. In order for a child to have Meckel-Gruber syndrome, both parents must carry copies of the defective gene. If both parents carry the defective gene, there is a 25% chance their child will have the condition....

One of the most salient facts of American life today is how disconnected the power structure is from the average citizen. In a vicious cycle that feeds on itself, America’s elites—including its liberal elite—live in their own neighborhoods, come from similar backgrounds, go to the same schools, and can go from cradle to grave never having a meaningful experience with the people who come from where I come from....

NEWSWEEK: You’ve been working without pay since last summer. That must be kind of tough. Douglas Holtz-Eakin: Yes. [Laughs] It has its interesting moments. At what point will the campaign start paying you again? I truthfully don’t know the answer to that. What we’re doing at the moment is trying to get the nomination locked down; it’s the march to 1,200 delegates. At that point, according to the plan [campaign manager] Rick Davis has outlined, we’ll rethink the campaign and move forward....

Dubbed the Professor Genki Pack, this pre-order bonus for Saints Row: The Third provides gamers with a special vehicle, outfit, and weapon to play around with on the streets of Stilwater. Each of the three bonus items carry a somewhat daredevil-esque theme, but are also tricked out with colorful patterns and interesting abilities. But these three pre-order items pale in comparison to the trailer that THQ has released to hype the pack....

Igarashi has worked in the industry since 1990 with his start as Assistant Director on Mouretsu Atarou, where he soon became embroiled in the Sailor Moon series as an episode director. Nowadays, he’s know for his wildly successful work as the director of not only Ouran, but also Soul Eater, Star Driver, and Bungo Stray Dogs. All directors have their own quirks and signatures, but sometimes it’s hard to put into words what their style is and how it enhances their work....

The Importance of Clean Indoor Air Clean indoor air was a concern for building owners before COVID-19, but the pandemic created a heightened awareness of it. The maintenance of HVAC systems is a major part of achieving optimal IAQ. The benefits of breathing clean indoor air are well-documented. We know that poor indoor air poses health risks. It can trigger asthma and allergy symptoms, and long-term exposure can lead to serious respiratory problems, heart disease and even cancer....

Where the original Mega Man Legacy Collection, including all of the classic NES Mega Man titles, stands as Mega Man’s most successful years, Mega Man Legacy Collection 2 is all about when Mega Man did some soul searching. Mega Man 7 debuted on the Super Nintendo Entertainment system to middling reviews. Mega Man 8 came years later to the PlayStation to even worse reviews. The main Mega Man series would then go into hibernation for over 10 years, though several spin-off series would keep the franchise warm in the interim....

First Five: 03-25-30-54-70Mega Ball: 09Megaplier: 3x Friday’s 01/17/20 jackpot was $103 million, with a cash-value option of $69.5 million. The total jackpot could have increased depending on the number of tickets sold around the country prior to the drawing. The winning numbers on Tuesday’s (01/14/20) previous drawing for the $91 million jackpot were: 09-11-13-31-47 with a Mega Ball of 11. The Megaplier was 2x. There was no grand prize winner from Tuesday’s drawing, but there was a ticket sold in Virginia that matched the first five white balls for the game’s second prize of $1 million....

First Five: 28-30-31-35-66Mega Ball: 14Megaplier: 2x Friday night’s 05/01/20 jackpot is $200 million, with a cash-value option of $161.8 million. The total jackpot could have increased depending on the number of tickets sold around the country prior to the drawing. The winning numbers on Tuesday (04/28/20) for the $186 million jackpot were: 13-19-53-54-63 with a Mega Ball of 17. The Megaplier was 3x. There was no grand prize winner from Tuesday’s drawing, nor was there a ticket sold that matched the first five white balls, and minus the gold Mega Ball, for the game’s second prize....

First Five: 05-20-22-61-70Mega Ball: 04Megaplier: 2x Friday night’s 05/08/20 jackpot was $231 million, with a cash-value option of $184.9 million. The total jackpot could have increased depending on the number of tickets sold around the country prior to the drawing. The winning numbers on Tuesday (05/05/20) for the $215 million jackpot were: 07-13-17-21-45 with a Mega Ball of 14. The Megaplier was 2x. There was no grand prize winner from Tuesday’s drawing, but there were four tickets sold—one each in California, North Carolina, Pennsylvania and West Virginia—that matched the first five white balls, and minus the gold Mega Ball, for the game’s second prize of $1 million....

Here are the winning numbers. First Five: 03-20-23-35-60Mega Ball: 16Megaplier: 3x Friday night’s 12/20/19 jackpot was $40 million, with a cash-value option of $27 million. The winning numbers on Tuesday (12/17/19) for the $372 million jackpot were: 22-30-53-55-56 with a Mega Ball of 16. The Megaplier was 2x. The grand prize winner from Tuesday’s drawing was from Ohio. In addition, there were four tickets sold that matched the first five white balls but just missed on the Mega Ball....

Soul Hackers 2 may send a more complicated message. It is very different from its predecessor in a lot of ways, from aesthetics to its gameplay, and that suggests other Megami Tensei franchises could get major reworks when Atlus decides to revisit them. There’s a good chance more Megami Tensei revivals are on the way given recent comments about expanding the Shin Megami Tensei brand, but fans shouldn’t expect predictable, traditional sequels to old games....

El popular servicio de Dotcom para compartir archivos fue cerrado en enero como parte de un juicio sobre infracción de copyright masivo interpuesto contra MegaUpload por los Estados Unidos. Dotcom ha estado insinuando durante varios meses a través de Twitter que está preparando una nueva versión de su famoso sitio. “MEGA volverá. Más grande. Mejor. Rápido. Gratuito y protegido de ataques”, aseguraba Dotcom en julio. Varias semanas más tarde volvía con la promesa de que el nuevo Mega sería “cien por cien seguro e imparable....

William and Kate will step foot on American soil for the first time since they became Prince and Princess of Wales, titles they took on after Queen Elizabeth II’s death. The couple will attend the Earthshot Prize ceremony on December 2 and a series of events in the days before, after touching down in Boston on Wednesday, November 30. On Tuesday, Meghan will give a speech on the power of women during a visit to Indianapolis, while on December 6 she will find out whether her Archetypes podcast will win a People’s Choice Award....

Markle has spoken extensively about how race has played a dominant role in the way she has been viewed and discussed since she became publicly involved in a relationship with Britain’s Prince Harry in 2016. Both Meghan and Harry have called out the British tabloid press for the racist undertones of reporting about the duchess and also spoken about the hatred this can inspire on social media message boards....

Mbappe made his full international debut in France’s 2-0 friendly defeat against Spain and put in an eye-catching performance alongside Kevin Gameiro and Antoine Griezmann in Deschamps’ three-pronged attack. Batelli indicated that he still has hope of the 18-year-old being made available for France Under-20s when they travel to South Korea in May, but admitted that Borussia Dortmund’s 19-year-old midfielder Ousmane Dembele will be required for France’s World Cup qualifier against Sweden on June 9....

While floods ravaged New Orleans in August 2005, Bush and McCain celebrated McCain’s birthday in Arizona. Susan Walsh / AP NEW ORLEANS–President Bush’s lackadaisacal response to the Hurricane Katrina crisis is pretty much a truism by now. But John McCain’s cameo role in the mess may soon make it into the highlight reel as well. As the deadly storm system moved ashore almost three years ago, sending fatal floods through New Orleans and the Gulf Coast, Bush was in Phoenix, on a tour aimed at boosting participation in what was then the administration’s new Medicare prescription-drug plan....

“The American people have had enough of this nonsense,” the Kentucky Republican, who was visibly frustrated, said from the floor. He added that there was “absolutely mindless obstruction going on on the other side while the public is waiting for us to act, while people are losing their jobs, losing their income and shutting down the economy.” Democrats prevented a procedural motion on the bill—just as they did Sunday—over accusations that it benefits corporations more than individuals....

The presser lacked drama, but did have a couple noteworthy moments courtesy of the UFC lightweight champion. McGregor looked over at Mayweather and told him that he made a big mistake wanting to face him and he plans on quieting everyone who feels he will lose. MORE: Five fights that defined McGregor’s career “I’m gonna f— this boy up, make no mistake,” McGregor said. “When it’s all said and done I’m going to feel a little bit sad....

This fight was supposed to take place in July, but a rib injury forced Aldo to pull out just weeks before the event. Chad Mendes took the fight on short notice and gave McGregor a real scare in the first round, taking him down, but was unable to do any serious damage. McGregor got up and dominated, before finishing Mendes in the second round. UFC 194: Weidman vs. Rockhold odds and pick...